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DNA

Courtesy Encyclopędia Britannica, Inc.

DEOXYRIBONUCLEIC ACID is an organic chemical of complex molecular structure that is found in cells and in many viruses. DNA codes genetic information for the transmission of inherited traits. 

The chemical DNA was first discovered in 1869, but its role in genetic inheritance was not demonstrated until 1943. In 1953, James Watson and Francis Crick determined that the structure of DNA is a double-helix polymer, a spiral consisting of two DNA strands wound around each other. Each strand is composed of a long chain of monomer nucleotides. The nucleotide of DNA consists of a deoxyribose sugar molecule to which is attached a phosphate group and one of four nitrogenous bases: two purines (adenine and guanine) and two pyrimidines (cytosine and thymine). The nucleotides are joined together by covalent bonds between the phosphate of one nucleotide and the sugar of the next, forming a phosphate-sugar backbone from which the nitrogenous bases protrude. One strand is held to another by hydrogen bonds between the bases; the sequencing of this bonding is specific--i.e., adenine bonds only with thymine, and cytosine only with guanine.

                                                                                    

  
 
The bases of one helical strand in DNA are paired with complementary bases of the other strand by hydrogen bonds: adenine (A) is paired with thymine (T) and cytosine (C) is paired with guanine (G).

 

 
 

 The bases of one helical strand in DNA are paired with complementary bases of the other. The configuration of the DNA molecule is highly stable, allowing it to act as a template for the replication of new DNA molecules, as well as for the production (transcription) of the related RNA (ribonucleic acid) molecule. A segment of DNA that codes for the cell's synthesis of a specific protein is called a gene.

Portion of polynucleotide chain of deoxyribonucleic acid (DNA). The inset shows the corresponding pentose sugar and pyrimidine base in ribonucleic acid (RNA).

 

DNA replicates by separating into two single strands, each of which serves as a template for a new strand. 

A possible method for the replication of DNA according to Watson and Crick. The arrows indicate the direction of rotation.

 The new strands are copied by the same principle of hydrogen-bond pairing between bases that exists in the double helix. Two new double-stranded molecules of DNA are produced, each containing one of the original strands and one new strand. This "semiconservative" replication is the key to the stable inheritance of genetic traits. Within a cell, DNA is organized into dense protein-DNA complexes called chromosomes

The genetic material of viruses may be single- or double-stranded DNA or RNA. Retroviruses carry their genetic material as single-stranded RNA and produce the enzyme reverse transcriptase, which can generate DNA from the RNA strand.

DNA Test

Courtesy Encyclopędia Britannica, Inc.

   

 
   
 

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