Alzheimer's disease is a progressive Dementing disorder characterised by the neuropathological findings of loss of cerebral neurons accompanied by senile plaques and neurofibrillary tangles.

• The earliest symptoms of AD is usually insidiously progressive disorder of memory.
  
• Disturbances of judgement occur frequently and at times leading to disastrous personal and financial losses.
  
• Gross behavioural disturbances may be caused like : -
  suspiciousness progressing to frank paranoia.
  halucinations, both visual and auditory.
  
• Disturbances of motor activity - wandering, purposeless movements, inappropriate acts, aggressiveness.
  
• Reversal of day and night - wandering during the night.
  
• Unexplained phobias and anxieties.
  
• In later stages - incontinence of urine and stool.
  
• A small percentage of AD patients develop myoclonus and seizures.

• Patients of AD may develop symptoms of Parkinson's disease like bradykinesia, rigidity, hypokynetic speech, slow shuffling gait. Usually these symptoms show poor response of Levodopa in contrast to excellent response in PD.

Waning signs for Alzheimer's

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